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Rapid, accurate diagnosis and treatment in an emergency-room or intensive-care setting are important in order to prevent the potentially life-threatening central nervous system and systemic effects of intrathecal baclofen withdrawal.

After 1 to 3 months of treatment when patients had reached their maximal tolerated dosage, the results showed decrease in motor tone and the deep tendon reflex of the affected lower extremities but there was no statistical difference in the spasm frequency.

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Comparison of 198 patients who used intrathecal baclofen (ITB) and 315 who used oral medications showed that those who used ITB had lower levels of spasticity, less leg stiffness, less pain, and fewer spasms.

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Manual dexterity and strength also do not improve by reducing muscle tone, which means that treatment of spasticity may not lead to an improvement in function.

They are chemically the same and since the active ingredient is identical they have the same medical effect as brand drugs.

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